LIVE ANTIVARIOLIC VACCINES

A comparative study of two live measles vaccines in Iran

Live Attenuated Measles Mumps and Rubella Vaccines:

Abbreviations: MMR: Measles, Mumps and Rubella; WHO: World Health Organization; SSPE: Subacute Sclerosing Panencephalitis; PAHO: Pan American Health Organization; CRS: Congenital Rubella Syndrome; MR: Measles-Rubella; GSK: GlaxoSmithKline; EZ: Edmonston Zagreb; CEF: Chicken Embryo Fibroblast; IBD: Inflammatory Bowel Disease; CDC: Centers for Disease Control and Prevention; SSPE: Subacute Sclero...

Lactic acid bacteria as live vaccines.

Mucosal routes for vaccine delivery offer several advantages over systemic inoculation from both immunological and practical points of view. The development of efficient mucosal vaccines therefore represents a top prority in modern vaccinology. One way to deliver protective antigens at the mucosal surfaces is to use live bacterial vectors. Until recently most of these were derived from attenuat...

Recombinant vaccinia viruses as live vaccines.

Recombinant vaccinia viruses can be constructed that express foreign antigens. These viruses retain their infectivity and synthesise the foreign gene product in tissue culture and in vaccinated animals. Following vaccination, specific antibody and cell-mediated immune responses are generated against the foreign protein and in several cases these have protected the animal against subsequent chal...

Actinobacillus pleuropneumoniae for Use in Live Vaccines

Clonal, noniridescent mutants ofActinobaciUlus pleuropneumoniae serotypes 1 and 5 were isolated following chemical mutagenesis with ethyl methanesulfonate. The absence of any detectable capsule was confirmed by inhibition radioimmunoassay. There were no differences between the parent and mutant strains in lipopolysaccharide or protein electrophoretic profiles or in hemolytic activity. There was...